COUP-TFII plays pivotal role in obesity, metabolic syndrome
SemBioSys Genetics Inc., a biotechnology company developing protein pharmaceuticals in crop plants, has announced that it has initiated a phase I/II clinical trial of its plant-produced insulin with the first injection of its drug in humans. The trial, taking place in the United Kingdom (UK), will include up to 30 healthy volunteers in a three-arm study
Full Post: SemBioSys begins phase I/II trial of insulin produced in plant seeds
A protein known to play a role in development and the formation of organs is also an important factor in the control of obesity and diabetes, said researchers from Baylor College of Medicine in a report that appears in the current issue of the journal Cell Metabolism.
Drs. Ming-Jer and Sophia Tsai, professors of molecular and cellular biology at BCM, have studied COUP-TFII (Chicken Ovalbumin Upstream Promoter Transcription Factor II) for decades, but only when they bred mice that had only one gene copy for the factor did they find that the animals had smaller fat cells and increased energy metabolism as well as enhanced response to insulin.
“If a mouse loses one copy of the gene, the animal becomes lean,” said Ming-Jer Tsai. “It is more sensitive to the effects of insulin and resistant to obesity from a high fat diet.”
Their studies raise the likely possibility that one can use COUP-TFII as a potential drug target for diabetes and obesity treatment.
Identifying a drug that could reduce the effect of COUP-TFII activity has become a future focus for their research, said Sophia Tsai.
“We don’t need to inhibit it totally,” she said. “Partial inhibition will do the trick as when you lose one copy of the gene, your fat cells are already much smaller and the animal is lean.”
The animals not only have less fat, they also have more muscle and burn more energy, said Ming-Jer Tsai.
New evidence in mice bolsters the notion that a version of a gene earlier shown to protect lean people against weight gain and insulin resistance can have the opposite effect in those who eat a high-fat diet and are heavier, reveals a report in the January 7th issue of the journal Cell Metabolism, a Cell
Full Post: People with Ala12 gene variant need to watch out for high fat in their diets
After you eat a burger and fries or other fat-filled meal, a protein produced by the liver may send a signal that fat is on the way, suggests a report in the December issue of the journal Cell Metabolism, a Cell Press publication. Researchers have found in mice that the liver produces a protein called
Full Post: Adropin protein produced by the liver sends signal that fat is on the way in response to high-fat foods
French scientists have found a drug they say tricks the body into burning off fat - and it even works on a high-fat diet. Reducing calorie consumption by about 20% has been shown to slow down the aging process, improve endurance and protect against diet-induced obesity and metabolic diseases such as diabetes. Last year researchers
Full Post: New drug tricks the body into burning off fat
Researchers at Albert Einstein College of Medicine of Yeshiva University have found that overactivity of a brain enzyme may play a role in preventing weight gain and obesity. The findings were reported in Cell Metabolism. To understand what drives hunger and causes metabolic disease, many scientists have focused on the hypothalamus, an almond-sized structure located
Full Post: Overactive brain enzyme may play role in preventing weight gain and obesity
A previously unknown mutation discovered in a common roundworm holds the promise of new treatments for obesity in humans, McGill University researchers say. Their study was published Dec. 3 in the journal Nature , and was funded by the Canadian Cancer Society and the Canadian Institutes of Health Research. In lean times, a normal Caenorhabditis
Full Post: C. elegans worms may hold key to new treatments for obesity in humans