A new era of intelligent cancer drug development has spurred a leap in the proportion of drugs reaching patients, according to a study by Cancer Research UK scientists published in Nature Reviews Drug Discovery. Scientists obtained data on 974 cancer drugs in clinical development, and calculated that there was a probability that 18 per cent
Full Post: ‘Intelligent’ cancer drug development boosts success rates
Two pregnancies and six cases of intermenstrual bleeding have been described in women using oral contraceptives, attributed to the use of Diflucan. This interaction (if such it is) is rare.
Two pregnancies have been reported, despite the use of oral contraceptives, attributed to an interaction with single 150 mg doses of Diflucan. Intermenstrual bleeding has also been described in six other women on oral contraceptives when given a single 150 mg dose of Diflucan. No withdrawal bleeding was reported m one other patient.
In contrast to these reports, a study in 10 women taking combined oral contraceptives found no evidence that a single 50 mg dose of Diflucan or 50 mg Diflucan daily for 10 days had significant effects on the pharmacokmetics of an oral contraceptive (30 g ethmyloestradiol and 150 mg leveonorgestrel). During clinical trials in which single 150 mg doses of Diflucan were used by over 700 women taking oral contraceptives, no evidence of an interaction was seen.
Not understood Unlike ketoconazole, Diflucan appears to have little effect on liver enzyme activity (P450-cytochrome mediated reactions).
Although the contraceptive failures and intermenstrual bleeding cited here have been attributed to the use of Diflucan, this interaction is not clearly established The weight of evidence suggests that contraceptive failure is very unlikely if Diflucan is given, however spotting and breakthrough bleeding are possible signs of diminished contraceptive effectiveness and the ultracauhous might consider advising the additional use of a barrier method of contraception if pregnancy is to be avoided more certainly.
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Introduced in the 1960s, oral contraceptives have been used by about 80 percent of women in the United States at some point in their lives. For women without pre-existing risks for heart disease, the early formulations were generally safe, and the newer ones appear to be even safer, but all the risks and benefits are
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A marked increase in the effects of warfarin with bleeding has been seen in a small number of patients when concurrently treated with erythromycin, but most patients are unlikely to develop a clinically important interaction. This interaction has also been seen in a patient on nicoumalone (acenocoumarol). A case report describes an elderly woman on warfarin,
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Diflucan is one of the drugs that are commonly applied in treating fungus-based infections. The drug is primarily used to treat yeast infection and toe nail fungus. Diflucan functions by preventing the development of fungus so as to arrest the infection. It does this by enhancing the permeability of cellular membranes, which then results in the
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According to the Vatican’s official newspaper, the contraceptive pill is a major cause of male infertility in the West and is also polluting the environment. An article in L’Osservatore Romano claims there is substantial evidence available to show that the environment is being flooded with synthetic female hormones because of widespread use of oral contraceptives
Full Post: Vatican blames the Pill for environmental pollution
Researchers at Wake Forest University School of Medicine may be one step closer to understanding why past oral contraceptive use dramatically lowers the risk of ovarian and uterine cancers later in life. While studying the effect of post-menopausal dietary soy consumption on estrogen metabolism in cynomolgus monkeys, Latanya M. Scott, Ph.D., discovered that monkeys
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