Johns Hopkins researchers have used fruit flies to gain new insights into a brain-damaging disorder afflicting children. Their work suggests a possible therapy for the disease, for which there is currently no treatment. The researchers genetically modified flies to exhibit symptoms of mucolipidosis type IV (ML4), a disease in which nerve cells in the brain
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By manipulating the appearance of a chronically achy hand, researchers have found they could increase or decrease the pain and swelling in patients moving their symptomatic limbs.
The findings - reported in the November 25th issue of Current Biology, a Cell Press publication - reveal a profound top-down effect of body image on body tissues, according to the researchers.
“The brain is capable of many wonderful things based on its perception of how the body is doing and the risks to which the body seems to be exposed,” said G. Lorimer Moseley, who is now at the Prince of Wales Medical Research Institute in Australia. (The work was done at the University of Oxford.)
In the study, the researchers asked ten right-handed patients with chronic pain and dysfunction in one arm to watch their own arm while they performed a standardized set of ten hand movements. The participants repeated the movements under four conditions: with no visual manipulation, while looking through binoculars with no magnification, while looking through binoculars that doubled the apparent size of their arm, and while looking through inverted binoculars that reduced the apparent size of their arm.
While the patients’ pain was always worse after movement than it was before, the extent to which the pain worsened depended on what people saw. Specifically, the pain increased more when participants viewed a magnified image of their arm during the movements, and - perhaps more surprisingly - the pain became less when their arm was seen through inverted binoculars that minimized its size.
The degree of swelling too was less when people watched a “minified” image of their arm during movements than when they watched a magnified or normal image, the researchers reported.
They aren’t yet sure how this phenomenon works at the level of neurons. However, the researchers said, a possible philosophical explanation comes from the notion that protective responses - including the experience of pain - are activated according to the brain’s implicit perception of danger level. “If it looks bigger, it looks sorer and more swollen,” Moseley said. “Therefore, the brain acts to protect it.”
While he said the findings don’t mean that pain is any less real, they may lead to a new therapeutic approach for reducing pain. His team is now testing visual manipulations as an analgesic strategy for use in clinical settings.
http://www.cellpress.com/
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