Epilepsy drug valproate may increase risk of autism in children
Daiichi Sankyo Company, Limited, has announced that it has initiated its pivotal Phase III trial for DU-176b, an investigational oral Factor Xa inhibitor, in patients with atrial fibrillation. DU-176b is being developed solely by Daiichi Sankyo. The Phase III global study, Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation (ENGAGE-AF TIMI 48),
Full Post: Daiichi Sankyo starts trial of investigational factor Xa inhibitor for atrial fibrillation
A new study shows that women who take the epilepsy drug valproate while pregnant may significantly increase their child’s risk of developing autism.
The preliminary research is published in the December 2, 2008, print issue of Neurology ?, the medical journal of the American Academy of Neurology.
The ongoing study involves 632 children, nearly half of whom were exposed to epilepsy drugs during gestation. Of the children whose mothers took epilepsy drugs while pregnant, 64 were exposed to valproate, 44 to lamotrigine, 76 to carbamazepine and 65 to other epilepsy drugs. Of the 632 children in the study, nine have been diagnosed with autism and one has shown symptoms of the disorder. The children were tested at one, three and six years old. Two-thirds of the children were six years old by the end of the study.
The study found seven of the children with autism had mothers who took an epilepsy drug while pregnant, four of those children were exposed to valproate while a fifth child’s mother took a combination of valproate and lamotrigine. The children whose mothers were given valproate during pregnancy were seven times more likely to develop autism compared to children whose mothers did not take an epilepsy drug while pregnant. This risk was not seen with the other epilepsy drugs. None of the children in the study had any known family history of autism.
“The potential risk for autism in this study was substantial for children whose mothers took valproate while pregnant, but more research needs to be done since these are early findings,” says study author Gus Baker, PhD, FBPsS, of the University of Liverpool in the United Kingdom.”However, women who take valproate while pregnant should be informed of the possible risks of autism and are encouraged to discuss them with their doctor. Those who are taking valproate should not stop their treatment without speaking to their doctor first.”
Other studies have shown that valproate is more likely to cause birth defects than other epilepsy drugs.
Symptoms of autism include difficulty in language development, a lack of attention, social problems and the inability to understand other people’s feelings.
Nitrofurantoin is prescribed for the treatment of bacterial infections. Always take Nitrofurantoin drug as per your doctor’s advise. It should be taken with food and the oral suspension can be mixed with water, fruit juice and milk and taken. While you are on Nitrofurantoin medication, you should have to complete the whole dose. If the
Full Post: Nitrofurantoin is used for the treatment of bacterial infections
Repeated miscarriages and hormone treatment for infertility give an increased risk of pre-eclampsia among pregnant women. This comes from a new study from the Norwegian Institute of Public Health. More than 20 000 first-time mothers from the Norwegian Mother and Child Cohort Study (MoBa) were included in the study. Normal risk First-time mothers
Full Post: Repeated miscarriages and hormone treatment for infertility increase pre-eclampsia risk
A new Mayo Clinic study found that it is generally safe to withdraw anti-seizure medications in children with epilepsy who have achieved seizure-freedom while on the medication. Researchers found that these children were not at high risk of subsequently developing intractable epilepsy. The study will be presented on Sunday, Dec. 7, at the American Epilepsy
Full Post: Study finds it generally safe to withdraw anti-seizure medication in children with epilepsy
New research by British scientists means prenatal testing for autism is a possibility, but has evoked calls for an ethical debate on the issue. A study by researchers at the autism research centre of Cambridge University has found that high levels of testosterone in the amniotic fluid of pregnant women was linked to autistic traits,
Full Post: Possible test for autism raises calls for an ethical debate
After a doctor at Adelaide’s Women’s and Children’s Hospital tested positive for tuberculosis (TB), authorities say as many as 300 babies have been identified who may have come into contact with the doctor and could be at risk. About 75 of the children are too young to be tested but have been given preventive
Full Post: As many as 300 children could be at risk of TB from hospital doctor