Neuralstem enters stem cell collaboration for Huntington’s disease in Germany
With up to half of a person’s body mass consisting of skeletal muscle, chronic inflammation of those muscles - which include those found in the limbs - can result in significant physical impairment. According to University of Illinois kinesiology and community health professor Kimberly Huey, past research has demonstrated that the antioxidant properties of Vitamin
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Neuralstem, Inc. announced today that it has entered into a collaboration with Professor Guido Nikkah Ph.D, of Albert-Ludwigs-University in Freiburg, Germany, to advance development of Neuralstem’s human neural stem cell therapies.
The collaboration with Professor Nikkah will focus on Huntington’s disease.
“We are pleased to have established this collaboration in Germany” said Richard Garr, Neuralstem President & CEO. “The goal of our work with Professor Nikkah will be to qualify our existing cGMP spinal cord cells into Professor Nikkah’s human trial program to treat Huntington’s disease. As we prepare to submit an IND to treat ALS with our stem cells in the U.S., we continue to look for strategic relationships in both Europe and Asia which will allow us to move the cells into humans. We believe that Professor Nikkah’s program is the most advanced of its kind in Western Europe, and we are excited about his working with our cells.”
Huntington’s disease (HD) results from genetically programmed degeneration of brain cells, called neurons, in certain areas of the brain. This degeneration causes uncontrolled movements, loss of intellectual faculties, and emotional disturbance. HD is a familial disease, passed from parent to child through a mutation in the normal gene. Each child of an HD parent has a 50-50 chance of inheriting the HD gene.
Neuralstem’s patented technology enables, for the first time, the ability to produce neural stem cells of the human brain and spinal cord in commercial quantities, and the ability to control the differentiation of these cells into mature, physiologically relevant human neurons and glia.
Major Central Nervous System diseases targeted by the Company with research programs currently underway include: Ischemic Spastic Paraplegia, Traumatic Spinal Cord Injury and ALS. The company’s cells have extended the life of rats with ALS (Lou Gehrig’s disease) as reported the journal TRANSPLANTATION, in collaboration with Johns Hopkins University researchers, and also reversed paralysis in rats with Ischemic Spastic Paraplegia, as reported in NEUROSCIENCE on June 29, 2007, in collaboration with researchers at University of California San Diego. The Company expects to file its first IND (Investigational New Drug) application with the FDA for ALS in the fall.
Neuralstem, Inc. announced this morning that it has filed an Investigational New Drug (IND) application with the U.S. Food and Drug Administration (FDA) to begin a clinical trial to treat amyotrophic lateral sclerosis (ALS or Lou Gehrig’s disease). The Company is planning to treat ALS patients through spinal injections of its stem cells via its
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According to Australian scientists help for spine injury victims could be just a sniff away - researchers from the University of New South Wales in Sydney say stem cells taken from the nose could help spinal injury victims regain movement. The team have conducted tests on paralysed rats which found they were able to
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Cells from the human nose are showing further promise in remediating spinal cord injury, according to research from the University of New South Wales (UNSW). Six weeks after injecting cells from the human nose (olfactory ensheathing glia) into the injured spinal cords of rats, the researchers found improvements in the animals’ movement. “We
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A study published in the current issue of Cell Transplantation (Vol.17, No. suggests that mature adipocytes - fat cells - could become a source for cell replacement therapy to treat central nervous system disorders. According to the study’s lead researcher, Dr. Yuki Ohta of the Institute of Medical Science, St. Mariana University School of
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Researchers at the University of Southern California (USC) have identified a novel mechanism in the regulation and differentiation of neural stem cells. Researchers found that the protein receptor Ryk has a key role in the differentiation of neural stem cells, and demonstrated a signaling mechanism that regulates neuronal differentiation as stem cells begin to grow
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