New guidelines for malignant melanoma
There are more than 76,000 end-stage renal disease patients waiting for one of the 17,000 kidneys transplanted each year, making a host rejection an unacceptable waste. Kidney transplantation is the preferred treatment for patients with end-stage renal disease. As the demand for organs exceeds the supply, blood group (ABO)-incompatible kidney transplantations have gained much importance
Full Post: Humoral immunity in kidney transplantation
The German Cancer Society has worked out new guidelines for the diagnosis and treatment of malignant melanoma - a disease with unfavorable prognosis.
Malignant melanoma is responsible for 90% of deaths from skin cancer. The incidence has increased 5-fold within the last 30 years and UV radiation is thought to be an important cause. Caucasian populations are most affected.
Claus Garbe of T?n University and his coauthors present the therapy of melanoma in the current edition of Deutsches ?zteblatt International ( Dtsch Arztebl Int 2008; 105: 845-51). Physicians should confirm the diagnosis by histopathology after complete surgical removal of the tumor. The German Cancer Society recommends specific treatments or therapeutic combinations, depending on the thickness of the tumor and its stage. For example, if the tumor has more than a specific thickness, it is recommended that the primary tumor should be surgically removed, together with the sentinel lymph nodes and in combination with immunotherapy. If surgical removal is not possible, radiotherapy is indicated. If there are distant metastases, physicians should perform monochemotherapy.
The American Society for Gastrointestinal Endoscopy (ASGE) heralds the recent news of a decline in U.S. cancer deaths and incidence rates, with colorectal cancer among the top three cancers with significant declines. ASGE, representing the specialists in colorectal cancer screening, is excited by the report showing that colorectal cancer deaths among men and women dropped
Full Post: ASGE encouraged by drop in colorectal cancer deaths
A University of British Columbia geneticist has discovered a gene mutation that can cause the most common eye cancer - uveal melanoma. Catherine Van Raamsdonk, an assistant professor of medical genetics in the UBC Faculty of Medicine and a team of researchers, have discovered a genetic mutation in a gene called GNAQ that could be
Full Post: Cause of uveal melanoma discovered, most common eye cancer
One of the most promising new ideas about the causes of cancer, known as the cancer stem-cell model, must be reassessed because it is based largely on evidence from a laboratory test that is surprisingly flawed when applied to some cancers, University of Michigan researchers have concluded. By upgrading the lab test, the U-M scientists
Full Post: Cancer stem-cell model tested by University of Michigan researchers
Research has shown that a particular receptor for the blood protein thrombin is overexpressed by highly metastatic melanoma cells. When activated, this receptor triggers a wide range of biochemical changes that increase the metastatic activity of melanoma cells. To prevent those biochemical changes from occurring, a team of investigators at The University of Texas
Full Post: Nanoparticle targets melanoma with siRNA
MR arthrography of the shoulder allows physicians to better identify tears and provides patients with an accurate diagnosis to determine whether or not surgery is needed, according to a study performed at Neuroskeletal Imaging in Merritt Island, Florida. The study included 150 patients who underwent both 3T MRI and MR arthrography examinations of the shoulder.
Full Post: MR arthrography is more accurate than MR in diagnosing shoulder tears