Pelvic girdle syndrome linked to diabetes
Cell Therapeutics, Inc. (CTI) has announced that the U.S. Food and Drug Administration (FDA) has accepted for filing and review, and has granted priority review status for, the supplemental Biologics License Application (sBLA) for use of Zevalin ([90Y]-ibritumomab tiuxetan) as consolidation therapy for patients with follicular B-cell non-Hodgkin’s lymphoma who achieve a response to first-line
Full Post: FDA accepts Zevalin supplemental biologics license application
Diabetes appears to be linked with an increased risk of pelvic girdle syndrome. This is shown in a new study from the Norwegian Institute of Public Health and Akershus University Hospital.
The study showed that five percent of women had had serious pelvic girdle syndrome (pain in both iliosacral ligaments and symphysis pubis) during their last pregnancy. Three percent of these women reported that they had diabetes, while diabetes was seen in only 0.5 percent of women who had not had severe pelvic girdle syndrome. Women with diabetes had therefore a seven times higher risk of severe pelvic girdle syndrome.
“Even after we controlled for other factors such as obesity, age and number of previous pregnancies, these numbers changed little”, said Malin Eberhard-Gran, a doctor and researcher at the Norwegian Institute of Public Health.
Eberhard-Gran is the first author of the article “Diabetes mellitus and pelvic girdle syndrome in pregnancy - is there an association?” which is presented in the journal Acta Obstetrica et Gyneocologica. The study was done in collaboration with Professor Anne Eskild who is employed by the Norwegian Institute of Public Health and Akershus University Hospital.
More knowledge of hormones as cause
The etiology of pelvic girdle syndrome is largely unknown. Mechanical (e.g. different types of load), traumatic and hormonal factors are believed to be significant. Pelvic girdle syndrome often appears in the first half of pregnancy, a period in which mechanical factors are unlikely to have much influence. This strengthens the hypothesis that hormones are an important cause.
The hormone relaxin helps to soften the pelvic joint and has been associated with pelvic girdle syndrome problems. Relaxin belongs to the family of insulin-like growth factors. It has been shown that women with type I diabetes have increased levels of relaxin in pregnancy. This indicates that there may be a biological link between diabetes and pelvic girdle syndrome, which has never been investigated previously.
Pelvic girdle syndrome in pregnancy can cause significant discomfort for many. Despite pelvic girdle syndrome being a common women’s health problem, we still know very little about the causes. Prevention should be based on solid knowledge of the causes and prognostic factors, of which more is needed.
“Our study suggests that there is a basis for further research on the role hormonal factors play in the development of pelvic girdle syndrome”, said Eberhard-Gran.
About the study
Women aged between 18-40 years who had given birth in two municipalities in Akershus were included in a questionnaire study. This included standardized questions about pain in the lower back and / or pelvis in the last pregnancy. In addition, they asked if they had or had other diseases, including diabetes, the last 12 months. A total of 1,816 mothers took part in the survey.
Repeated miscarriages and hormone treatment for infertility give an increased risk of pre-eclampsia among pregnant women. This comes from a new study from the Norwegian Institute of Public Health. More than 20 000 first-time mothers from the Norwegian Mother and Child Cohort Study (MoBa) were included in the study. Normal risk First-time mothers
Full Post: Repeated miscarriages and hormone treatment for infertility increase pre-eclampsia risk
Human parechovirus is a harmless virus which is encountered by most infants and displays few symptoms. Suspected of triggering type 1 diabetes in susceptible people, research methods need to take this “silent” virus into consideration. This comes from findings in a study from the Norwegian Institute of Public Health. This study was part of a
Full Post: Human parechovirus may trigger type 1 diabetes
Women who have had two or more induced abortions have a reduced risk of pre-eclampsia by 60%. It is not currently understood to what degree physical activity during pregnancy protects against pre-eclampsia, compared to previous studies. This is shown in two new studies from the Norwegian Institute of Public Health (NIPH) that use data from
Full Post: Reduced risk for pre-eclampsia among women who have aborted
Systematic use of pelvic lymphadenectomy (removal of the lymph nodes) does not improve disease-free or overall survival in women with early-stage endometrial cancer, according to a randomized trial published online November 25 in the Journal of the National Cancer Institute. The first site of metastasis for endometrial cancer is often the pelvic lymph nodes. However,
Full Post: Pelvic lymphadenectomy does not improve survival in early stage endometrial cancer
Smoking during the first trimester of pregnancy is clearly linked with an increased risk of cleft lip in newborns. Genes that play a role in detoxification of cigarette smoke do not appear to be involved. This is shown in a new study published in the journal Epidemiology. Oral clefts are one of the most common
Full Post: Smoking during the first trimester of pregnancy linked to oral clefts