Research looks at human gut when exposed to widely used antibiotic ciprofloxacin
Barr Pharmaceuticals, Inc. has confirmed that its subsidiary, Barr Laboratories, Inc., has initiated a challenge of the patent listed by Anesta in connection with its Amrix (cyclobenzaprine hydrochloride) extended-release capsules, 15mg and 30mg. Barr filed its Abbreviated New Drug Application (ANDA) containing a paragraph IV certification for a generic version of Amrix with the U.S.
Full Post: Barr Labs confirms patent challenge of Amrix extended-release capsules
We are always being told by marketers of healthy yogurts that the human gut contains a bustling community of different bacteria, both good and bad, and that this balance is vital to keeping you healthy.
But if you target the disease-causing bacteria with medicine, what might be the collateral damage to their health-associated cousins that call the human body home?
A new study by Les Dethlefsen et al, to be published this week in the online open-access journal PLoS Biology, looks into the changes that happen in the human gut when it is exposed to the widely used antibiotic, ciprofloxacin. Ciprofloxacin is prescribed for a number of conditions, including common afflictions such as urinary tract infections. It was previously believed to cause only modest harm to the abundant beneficial bacteria of the human body.
To investigate ciprofloxacin’s effect on health-associated bacteria a team of researchers, led by Dr. David Relman of Stanford University, catalogued types of bacteria present in the faeces of volunteers who were undergoing a course of treatment of ciprofloxacin. The DNA-analysis technique, massively-parallel pyrosequencing, was central to their approach, which is outlined in a companion paper scheduled for publication in PLoS Genetics on Friday the 21st of November. With this technique, the researchers examined the diversity and abundance of bacteria present in human faeces, identifying over 5,600 different bacterial species and strains. The dramatically increased detection power of this approach allowed the team to track carefully the changes in the gut’s bacterial community both during and after the course of treatment.
The study found that while the patients were undergoing treatment the overall abundance of approximately 30% of the species and strains was significantly affected. The effects varied greatly between individuals, with two of the subjects showing a strong reduction in diversity. The effects didn’t stop there. Once the course of treatment had been halted, it took up to four weeks for most strains of gut bacteria to return to their pre-treatment levels. Even six months later, some types of bacteria had not managed to return to pre-treatment abundance levels. During this time of population upheaval none of the patients in the study reported signs of gut-related problems.
The bacteria present in the human gut are responsible for various aspects of host nutrition, metabolism and immune responses. This study reveals aspects of resiliency in the indigenous microbiota when subjected to perturbation, but underlines the concern that antibiotic treatment, especially when prolonged or repeated, may have long-lasting effects on overall wellbeing that could go un-noticed.
Using a novel technique developed by Mitchell Sogin of the Marine Biological Laboratory (MBL) to identify different types of bacteria, scientists have completed the most precise survey to date of how microbial communities in the human gut respond to antibiotic treatment. Sogin, director of the MBL’s Josephine Bay Paul Center, and Susan Huse of the
Full Post: Antibiotics can cause pervasive, persistant changes to microbiota in human gut
Mention the phrase “diverse ecosystem,” and it conjures images of tropical rainforests and endangered coral reefs. It also describes the human colon. A new study from the Stanford University School of Medicine reveals in greater detail than ever before the full extent of the bacterial community inhabiting the human bowel - 10 times more diverse
Full Post: Gut check reveals vast multicultural community of bugs in bowels
When bacterial infections cause us to get really sick, the only way to get better is to go to the doctor. With the help of antibiotics, we can start to recover quickly. One such antibiotic is Augmentin which belongs to the penicillin family of drugs. A bacterial infection is different to a viral infection, therefore the
Full Post: Antibiotic Augmentin
Scientists have discovered a new way for bacteria to transfer toxic genes to unrelated bacterial species, a finding that raises the unsettling possibility that bacterial swapping of toxins and other disease-aiding factors may be more common than previously imagined. In a laboratory experiment, the scientists from NYU School of Medicine discovered that Staphylococcus aureus, a
Full Post: Discovery of new way for bacteria to transfer toxic genes to unrelated bacterial species
Researchers at the Johns Hopkins Bloomberg School of Public Health have found evidence of a novel pathway for potential human exposure to antibiotic-resistant bacteria from intensively raised poultry-driving behind the trucks transporting broiler chickens from farm to slaughterhouse. A study by the Hopkins researchers found increased levels of pathogenic bacteria, both susceptible and drug-resistant, on
Full Post: Study looks at exposure to antibiotic-resistant bacteria from transportation of poultry