Smoking prevention programs badly needed in China
Vical Incorporated has announced that the company’s Vaxfectin-formulated H5N1 pandemic influenza DNA vaccines induced T-cell responses against a matching strain of influenza virus and demonstrated cross-clade antibody responses against a different strain in a Phase 1 clinical trial. The company previously reported that the vaccines had achieved potentially protective levels of antibody responses in
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A study published this month in The New England Journal of Medicine, “Mortality Attributable to Smoking in China,” provides an estimate of the number of premature deaths in China in 2005 that were caused by smoking.
The study, carried out by a multinational team led by researchers at Tulane University School of Public Health and Tropical Medicine, offers additional strong documentation that smoking is a significant risk factor for mortality and disease.
“With a population of 1.3 billion, China is the world’s largest producer and consumer of tobacco and bears a large proportion of deaths attributable to smoking worldwide,” say the researchers. To estimate the number of deaths attributable to smoking in China, the team conducted a large cohort study in a nationally representative sample of Chinese adults. The investigators examined survey data on smoking and other risk factors collected on 167,871 Chinese adults (83,533 men and 86,338 women) who were 40 years or older. Initial data on the study group was collected by investigators for the China National Hypertension Survey in 1991. Smokers were defined as those who had smoked at least one cigarette a day for one year or more, and trained staff collected data on their demographic characteristics, medical histories, and life-style risk factors using a standard questionnaire. Follow-up evaluations were conducted with this group in 1999 and 2000.
The Tulane researchers observed that there was a significant dose-response association between “pack-years” smoked (i.e., the total number of cigarettes smoked) and deaths attributable to smoking in both men and women. The team estimated that in 2005, smoking caused a total of 673,000 deaths in China. The leading causes of smoking-related deaths were in the group were: cancer, 268,200; cardiovascular disease, 146,200; and respiratory disease, 66,800.
“These findings have important public health implications,” says Jiang He, principal investigator of the study and the Joseph S. Copes MD Chair in Epidemiology, professor of epidemiology and medicine, and chair of the Department of Epidemiology at Tulane University’s of Public Health and Tropical Medicine. “Data from our study and others provide strong evidence that tobacco smoking causes an increased risk of cancer, vascular disease and respiratory disease in China and elsewhere.”
The Tulane study did report a lower relative risk associated with smoking in China than have some studies carried out in Western populations. This lower relative risk noted among Chinese smokers may reflect differences in smoking patterns in the populations, according to the researchers. Relevant differences probably include the lower numbers of cigarettes smoked in the past as well as the later age of smoking initiation in subjects currently dying from smoking-related diseases.
This study provides an urgent reminder, concluded the researchers, that there is continued need for strengthening of smoking prevention and cessation programs in China.
An analysis of previous studies indicates that smoking is significantly associated with an increased risk for colorectal cancer and death, according to an article in the December 17 issue of JAMA, the Journal of the American Medical Association. Although tobacco was responsible for approximately 5.4 million deaths in 2005, there are still an estimated 1.3
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Remember the cool girls, huddled together in high school restrooms, puffing their cigarettes? Well, here’s consolation for the nerds in the crowd: Those teen smokers are more likely to experience obesity as adults, according to a new study from Finland. Girls who smoke 10 cigarettes per day or more are at greatest risk, particularly for
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If you need another reason to quit smoking, consider that it may diminish your chances of being a parent or grandparent. Scientists at the University of Rochester Medical Center have found that women exposed to second hand smoke, either as adults or children, were significantly more likely to face fertility problems and suffer miscarriages. An
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Smoking during the first trimester of pregnancy is clearly linked with an increased risk of cleft lip in newborns. Genes that play a role in detoxification of cigarette smoke do not appear to be involved. This is shown in a new study published in the journal Epidemiology. Oral clefts are one of the most common
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