Specific features of childhood brain tumors may help guide prognosis
A new study suggests that patients with hepatitis C (HCV) who need a liver transplant should not receive an organ with high levels of fatty deposits (a.k.a. hepatic steatosis). HCV recurrence was more frequent and earlier among those transplanted with such livers. These findings are in the January issue of Liver Transplantation , a journal
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Specific histologic features of childhood medulloblastomas may provide insight into prognosis, according to an article in the new issue of Pediatric and Developmental Pathology.
Medulloblastomas are common, malignant, embryonal childhood tumors in the cerebellum. Individual histologic features such as nodules, balls or high cell density are used to divide the tumors into variants thought to modify survival estimates. The WHO classification of these tumors includes desmoplastic/nodular (DM), medulloblastoma with extensive nodularity (N), large cell medulloblastoma (LC), and anaplastic medulloblastoma (A).
During their research, the article’s authors found a difference in survival distribution for six features of medulloblastomas: high cell density, fine fibrillary stroma, necrosis, nodules, balls and prominent nucleoli. The presence of nodules, balls, fine fibrillary stroma and high cell density improved the survival outlook, whereas necrosis and prominent nucleoli worsened it.
“The presence of nodularity in medulloblastoma is important to improved survival likelihood, particularly when combined with balls and fine fibrillary stroma,” according to the article “Histologic Features and Prognosis in Pediatric Medulloblastoma,” by Shalini Verma, C. Jane Tavare, and Floyd H. Gilles. “Given the WHO-acknowledged ‘overlap’ of desmoplastic/nodular medulloblastoma and nodular medulloblastoma, we suggest these diagnoses be combined into a diagnosis of nodular medulloblastoma, with nodules, balls, and fine fibrillary stroma as defining criteria.”
The article also contends that three histologic features vital for LC and A diagnoses - large and intermediate size nuclei and prominent nucleoli - have poor read-reread reliability and suggests these be combined into a diagnosis of anaplastic/large cell medulloblastoma.
To read the entire study, http://www3.allenpress.com/pdf/pdpa_11.5_i1615-5742-11-5-337.pdf
Pediatric and Developmental Pathology is published by the Society for Pediatric Pathology and the Pediatric Pathology Society. Pediatric and Developmental Pathology is the premier journal dealing with the pathology of disease from conception through adolescence. For more information, see www.pedpath.org
Having dense breasts - areas that show up light on a mammogram - is strongly associated with increased breast cancer risk, but “why” remains to be answered. Now, by examining dense and non-dense tissue taken from the breasts of healthy volunteers, researchers from Mayo Clinic have found several potential links. In two studies being presented
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New research in mice and five independent collections of human breast tumors has enabled National Cancer Institute (NCI) scientists to confirm that genes for factors contributing to susceptibility for breast cancer metastasis can be inherited. The new findings support earlier results from the same laboratory and appear in the Jan. 1, 2009, issue of Cancer
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The monitoring and treatment of eye diseases that may cause blindness has taken a big leap forward, thanks to a new imaging technique that takes high quality colour photographs of the whole retina. Using the new technique called ‘TEFI’ (Topical Endoscopic Fundal Imaging), Professor Andrew Dick, David Copland and the team from the University
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Researchers used a new imaging technique to take high quality color photographs of the clinical stages of ocular inflammation in mice, and the technology could help in the monitoring and treatment of diseases of the eye that may cause blindness. The study, “The Clinical Time-Course of Experimental Autoimmune Uveoretinitis Using Topical Endoscopic Fundal Imaging with
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Cytori Therapeutics, Inc. reported preclinical study results, which demonstrate the potential benefit of adipose-derived stem and regenerative cells (ADRCs) for the treatment of damaged intervertebral discs, evidenced by significantly increased disc tissue density and disc-specific extracellular matrix components at 12-months post treatment in a large animal model. The data were presented today at the 2008
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