3.6 million Americans living with active, undiagnosed psoriasis, unaware of associated risks

Human calmodulin-like protein (CLP) is found in many cell types including breast, thyroid, prostate, kidney, and skin. The protein can regulate many cell activities and has a highly specific expression. Gaining an understanding about the expression of CLP in oral epithelial cells and its possible downregulation (or lack of production) in cancer may be a

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Armed with research concluding that psoriasis is associated with an increased risk of heart attacks and other cardiovascular conditions, Joel M. Gelfand, MD, MSCE, Assistant Professor of Dermatology at the University of Pennsylvania School of Medicine and colleagues released an editorial consensus in the American Journal of Cardiology today, calling for psoriasis patients to be educated about and screened for cardiovascular risk factors.

Dr. Gelfand’s latest research estimates that, in addition to the seven million Americans adults diagnosed with psoriasis, as many as 3.6 million Americans are living with active, undiagnosed psoriasis, unaware of the associated cardiovascular risk.

Dr. Gelfand’s previously published research, a focal point of the AJC consensus advisory, showed that patients with psoriasis have an increased risk of cardiovascular disease and heart attacks, particularly if their psoriasis is moderate to severe. In the largest study of nonhospitalized patients with psoriasis and coronary artery disease to date, where more than 130,000 patients were tracked for 5.4 years, Gelfand et al determined that psoriasis is an independent risk factor for a heart attack. Other research shows that hypertension, diabetes, elevated cholesterol, and obesity are also more common in patients with psoriasis than in the general population.

“Psoriasis patients, particularly those with severe disease, should be educated about their increased risk of blocked arteries and heart attacks, screened for major cardiovascular risk factors — such as elevated blood pressure or cholesterol — and treated for modifiable cardiovascular risk factors,” recommends Dr. Gelfand. “Psoriasis patients are encouraged to make lifestyle adjustments that will improve their overall cardiovascular health.”

In a separate article, published online in the Journal of the American Academy of Dermatology , Dr. Gelfand and University of Pennsylvania School of Medicine doctoral candidate Shanu Kohli Kurd, MHS, estimated that 600,000 to 3.6 million Americans are living with undiagnosed active psoriasis. A disparity was found as well - undiagnosed patients were more likely to be male, nonwhite, less educated and unmarried, compared to diagnosed patients.

“Given the serious medical conditions often associated with psoriasis, including metabolic disorders and cardiovascular disease, it is very important for people with a persistent rash to seek medical attention, especially if the rash is quite extensive,” said Dr. Gelfand.

The consensus paper was supported by an educational grant from Amgen. Dr. Gelfand has received consulting fees from Amgen; Genentech; Pfizer, New York, New York; Celgene, Summit, New Jersey; and Centocor, Horsham, Pennsylvania. Dr. Gelfand is a grants investigator for Amgen, Centocor, and Pfizer.

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According to new recommendations in the December 10 issue of The American Journal of Cardiology (AJC), published by Elsevier, new research is called for and patients with severe forms of the skin disease psoriasis should receive evaluation and possible treatment to reduce their risk of coronary artery disease (CAD). Psoriasis is a common skin disease

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Patients with the skin disease psoriasis appear more likely to have higher levels of leptin (a hormone produced by fat cells that may contribute to obesity and other metabolic abnormalities) than persons without psoriasis, according to a report in the December issue of Archives of Dermatology. Psoriasis is an autoimmune disease that results in a

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Online support communities appear to offer both a valuable educational resource and a source of psychological and social support for individuals with psoriasis, according to a report in the January issue of Archives of Dermatology. “Psoriasis currently affects approximately 0.6 percent to 4.8 percent of the world’s population,” according to background information in the article.

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As the nation’s growing population of breast cancer survivors ages, many patients will likely develop common chronic illnesses like diabetes and heart disease, and they’ll need specialized care to balance those problems with the late effects of cancer therapies they received. They’ll also need screenings and advice about new strategies for preventing recurrences of their

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A research team led by Nancy Speck, PhD, Professor of Cell and Developmental Biology at the University of Pennsylvania School of Medicine, has identified the location and developmental timeline in which a majority of bone marrow stem cells form in the mouse embryo. The findings, appearing online this week in the journal Nature, highlight critical

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