Blocking Myc proteins stops ovarian cancer cell cycle in its tracks
Glucophage is a drug prescribed for people who are type 2 diabetic. The drug should be taken with food and it has to be continuously taken for better results. The drug is an extended-release tablet and it should only be swallowed. Crushing, braking or chewing the drug will release more of the drug into the
Full Post: Glucophage is a medication to treat diabetes
Ovarian cancer cells are “addicted” to a family of proteins produced by the notorious oncogene, MYC.
Blocking these Myc proteins halts cell proliferation in the deadliest cancer of the female reproductive system, according to a presentation by University of California, Berkeley scientists at the American Society for Cell Biology (ASCB) 48th Annual Meeting, Dec. 13-17, 2008 in San Francisco.
In 30-60 percent of human ovarian tumors, MYC is overly active, or amplified, usually as a result of extra chromosomal copies of the cancer-causing gene.
The extra MYC encourages the ovarian cells to manufacture too much c-Myc, a protein that regulates other genes involved in cellular growth and proliferation. The presence of excessive c-Myc protein drives healthy cells down the cancer development pathway.
Using RNA interference (RNAi) to block c-Myc protein, Berkeley scientists, Tulsiram Prathapam and G. Steven Martin, treated lab cultures of human ovarian cancer cells that contained amplified MYC. RNAi’s blocking of the c-Myc protein stopped the cancer cell cycle in its tracks.
But RNAi blocking of c-Myc protein in lab cultures in which the MYC gene was not experimentally amplified did not affect ovarian cancer cell growth.
The scientists suspect that even when c-Myc was blocked in non-amplified cells, other forms of the protein ⎯ L-Myc and N-Myc ⎯ likely were present and continued to maintain cell proliferation.
By using small interfering RNA (siRNA) to silence L-Myc and N-Myc, the researchers succeeded in shutting down the growth of the non-amplified MYC tumors.
These therapies also were applied to lab cultures of normal ovarian surface epithelial cells. Blocking all the Myc proteins in the normal cultures did not affect cell proliferation, perhaps because the RNAi and siRNA “therapies” are effective only when the MYC genes are abnormally active.
The scientists hope that their results may lead to a new approach to treating ovarian cancer, the most lethal cancer of the female reproductive system.
Ovarian cancer cells are “addicted” to a family of proteins produced by the notorious oncogene, MYC, and blocking these Myc proteins halts cell proliferation in the deadliest cancer of the female reproductive system, according to a presentation by University of California, Berkeley scientists at the American Society for Cell Biology (ASCB) 48th Annual Meeting, Dec.
Full Post: Researchers stop ovarian cancer cell cycle in its tracks
A protein known to inhibit the growth of ovarian cancer works in part by forcing cancer cells to eat themselves until they die, researchers at The University of Texas M. D. Anderson Cancer Center report in the Nov. 15 issue of Cancer Research. The research team also found that expression of the protein, known as
Full Post: PEA-15 protein points to potential targeted approach for ovarian cancer
A new study reveals critical molecular mechanisms associated with the development and progression of human neuroblastoma, the most common cancer in young children. The research, published by Cell Press in the January 6th issue of the journal Cancer Cell, may lead to development of future strategies for treatment of this aggressive and unpredictable cancer. Neuroblastoma
Full Post: New insight into critical molecular mechanisms involved in aggressive childhood cancer
A single tumor-suppressing gene is a key to understanding, and perhaps killing, dormant ovarian cancer cells that persist after initial treatment only to reawaken years later, researchers at The University of Texas M. D. Anderson Cancer Center report in the December Journal of Clinical Investigation. The team found that expression of a gene called ARHI
Full Post: Dormant cancer cells rely on cellular autophagy to survive
CANCER RESEARCH UK scientists have linked cancer clues in faulty cells to provide a new route to cancer development, reveals a study published in Developmental Cell. Cancer is a disease caused by uncontrolled cell growth and division and understanding the complex molecular networks inside cells which regulate these processes is fundamental to understanding what goes
Full Post: Scientists establish completely new route to cancer development