Discovery of mechanism for dental pain
An innovative approach for implanting a new aortic heart valve without open-heart surgery is being offered to patients at NewYork-Presbyterian Hospital/Columbia University Medical Center. Known as the PARTNER (Placement of AoRTic traNscathetER valves) trial, this Phase 3 multicenter study is being led by national co-principal investigators Dr. Martin Leon and Dr. Craig Smith and is
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Researchers at Oregon Health & Science University’s School of Dentistry have discovered a novel function of the peptide known as Nerve Growth Factor (NGF) in the development of the trigeminal nerve.
The trigeminal nerve provides the signaling pathway for periodontal pain, dental surgical pain, and pain associated with temporomandibular disorder, trigeminal neuralgia, migraine, and other neuropathic and inflammatory conditions.
The study is posted online in the journal Neuropeptides and will appear in print issues of that journal in early 2009.
Working with researchers in the dental school departments of Endodontology and Integrative Biosciences, second-year endodontology resident and lead author of the study, Leila Tarsa, D.D.S., M.S., found a new mechanism involved in establishing junctions - known as synapses - between trigeminal nerve cells. Nerve cells communicate with one another through chemicals called transmitters that are released at synapses. The transmitter release from nerve cells endings is possible only if aided by several molecules that are critical for proper function of the synapse. Tarsa’s research shows that NGF promotes transport of one of the molecules (called synaptophysin) from the nerve cell body to its ending.
“The data indicate that NGF participates in formation of neuronal connections in the trigeminal system,” said Agnieszka Balkowiec, M.D., Ph.D., OHSU School of Dentistry assistant professor of integrative biosciences and OHSU School of Medicine adjunct assistant professor of physiology and pharmacology, who is the senior author of the study and whose lab hosted the research. “This study has broad implications for trigeminal nerve regeneration.”
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Researchers at Oregon Health & Science University’s School of Dentistry have found that a significant percentage of dental patients with the inflammatory diseases irreversible pulpitis and apical periodontitis also have the Epstein-Barr virus. The Epstein-Barr virus is an important human pathogen found in more than 90 percent of the world population. It is associated with many
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A University of South Carolina study of children’s dental health has found that nearly one-fourth of the nation’s children have had no dental care in at least a year. Conducted by researchers at the S.C. Rural Health Research Center at the Arnold School of Public Health, the study found that nearly 32 percent of Hispanic
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