Eating eggs when pregnant may help prevent breast cancer in offspring
Research conducted by a team in Switzerland suggests that a family of genes involved in regulating the expression of other genes in the brain is responsible for helping us deal with external inputs such as stress. Their results, appearing in the December 11 advance online version of the journal Neuron, may also give a clue
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A stunning discovery based on epigenetics (the inheritance of propensities acquired in the womb) reveals that consuming choline - a nutrient found in eggs and other foods - during pregnancy may significantly affect breast cancer outcomes for a mother’s offspring.
This finding by a team of biologists at Boston University is the first to link choline consumption during pregnancy to breast cancer. It also is the first to identify possible choline-related genetic changes that affect breast cancer survival rates.
“We’ve known for a long time that some agents taken by pregnant women, such as diethylstibesterol, have adverse consequences for their daughters,” said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal . “But there’s an upside. The emerging science of epigenetics has yielded a breakthrough. For the first time, we’ve learned that we might be able to prevent breast cancer as early as a mother’s pregnancy.”
The researchers made the discovery in rats by studying females whose mothers were fed varying amounts of choline during pregnancy. Different groups of pregnant rats received diets containing standard amounts of choline, no choline at all, or extra choline. Then the researchers treated the female offspring with a chemical that causes cancer of the mammary gland (breast cancer). Although animals in all groups developed mammary cancer, the daughters of mothers that had received extra choline during pregnancy had slow growing tumors while daughters of mothers that had no choline during pregnancy had fast growing tumors.
“Our study provides additional support for the notion that choline is an important nutrient that has to be considered when dietary guidelines are developed,” said Krzysztof Blusztajn, Ph.D., Professor of Pathology at Boston University and the study’s senior researcher. “We hope it will be possible to develop nutritional guidelines for pregnant women that ensure the good health of their offspring well into old age.”
The researchers also found multiple genetic and molecular changes in the rats’ tumors that correlated with survival outcomes. For example, the slow growing tumors in rats had a genetic pattern similar to those seen in breast cancers of women who are considered to have a good prognosis. The fast growing tumors in mice had a pattern of genetic changes similar to those seen in women with a more aggressive disease. The researchers also found evidence that these genetic changes may result from the way that choline affects modifications of the DNA within the mammary gland of fetuses as they develop in the womb.
The National Cancer Institute estimates that there will be more than 184,000 new cases of breast cancer in 2008 and more than 40,000 deaths. Treatments for women suffering from breat cancer range from hormone therapy to surgery.
A new study shows that women who take the epilepsy drug valproate while pregnant may significantly increase their child’s risk of developing autism. The preliminary research is published in the December 2, 2008, print issue of Neurology ?, the medical journal of the American Academy of Neurology. The ongoing study involves 632 children, nearly half
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A new study published online in The FASEB Journal shows that the equivalent of one dose of caffeine (just two cups of coffee) ingested during pregnancy may be enough to affect fetal heart development and then reduce heart function over the entire lifespan of the child. In addition, the researchers also found that this relatively
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Women who smoke during pregnancy risk delivering aggressive kids according to a new Canada-Netherlands study published in the journal Development and Psychopathology. While previous studies have shown that smoking during gestation causes low birth weight, this research shows mothers who light up during pregnancy can predispose their offspring to an additional risk: violent behaviour. What’s
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Women can usually keep using the same asthma drugs they were using before they got pregnant. Budesonide sprays are the best studied and can be regarded as safe. More trials of other essential medicines are necessary however. According to the German Institute for Quality and Efficiency in Health Care (IQWiG), more data from trials could
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New Australian research has found that even minor, everyday stress during pregnancy possibly affects a developing foetus. Researchers from the Telethon Institute for Child Health Research in Western Australia say stress has an affect on the brain of the growing foetus and can cause problem behaviour by the time the child reaches pre-school age. According
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