Exciting cancer discovery
CANCER RESEARCH UK scientists have shown for the first time how a natural ‘defence’ gene involved in fighting infections such as common colds, can be triggered by hormones to ignite and drive cancers like breast, ovarian, and possibly prostate cancer. Their findings are published in the Journal of Experimental Medicine. A team of researchers at
Full Post: Natural ‘defence’ gene reveals how oestrogen fuels cancer
Metastasis is the ability of cancer cells to spread from a primary site, to form tumours at distant sites.
It is a complex process in which cell motility and invasion play a fundamental role. Essential to our understanding of how metastasis develops is identification of the molecules, and characterisation of the mechanisms that regulate cell motility. Hitherto, these mechanisms have been poorly understood. Now, a team of researchers lead by Professor Marco Falasca at Barts and The London School of Medicine and Dentistry has shown not only that the enzyme phospholipase C?(PLC? plays a crucial role in metastasis formation, but that down regulation of PLC?expression is able to revert metastasis progression.
The team investigated the role of PLC?in cell invasion and metastasis using different approaches to modulate its expression in highly invasive cancer cell lines. Their results showed that PLC?is required for breast cancer cell invasion and activation of the protein Rac1. They revealed a functional link between PLC?and Rac1 that provides insight into processes regulating cell invasion.
Professor Falasca explained: “Consistent with these data we detected an increase in PLC1 expression in metastases compared to primary tumours in breast cancer patients. Therefore PLC?is critical for metastasis formation, and development and inhibition of this enzyme has a therapeutic potential in the treatment of metastasis dissemination.”
“This is an exciting discovery. He has shown that turning off this molecule prevents metastasis. The simple fact is that if you stop metastasis, you stop cancer from killing people. We now need to focus on developing drugs that can block PLC?”
Few things are as tiresome as house hunting and moving. Unfortunately, metastatic cancer cells have the relocation process down pat. Tripping nimbly from one abode to another, these migrating cancer cells often prove far more deadly than the original tumor. Although little has been known about how these rogue cells choose where to put
Full Post: Researchers gain new insight into cancer metastasis
Canadian researchers have identified a new protein in the progression of breast cancer. According to a recent study from the Université de Montréal and the University of Alberta, published in the Journal of Biological Chemistry, the protein ARF1 plays a critical role in cancer cell growth and the spread of tumours. Targeting this protein with
Full Post: Discovery of new protein that triggers breast cancer
If scientists knew exactly what a breast cancer cell needs to spread, then they could stop the most deadly part of the disease: metastasis. New research from the University of North Carolina at Chapel Hill School of Medicine takes a step in that direction. Carol Otey, Ph.D. and UNC colleagues reduced the ability of breast
Full Post: Palladin may play important role in metastasis of breast cancer cells
University of Texas Medical Branch at Galveston researchers have identified a promising new target in the battle against colorectal cancer - a biochemical pathway critical to the spread of tumors to new locations in the body. If this “survival pathway” can be successfully blocked under clinical conditions, the result would be a much-needed new therapy
Full Post: Discovery of promising new target in the battle against colorectal cancer
New research in mice and five independent collections of human breast tumors has enabled National Cancer Institute (NCI) scientists to confirm that genes for factors contributing to susceptibility for breast cancer metastasis can be inherited. The new findings support earlier results from the same laboratory and appear in the Jan. 1, 2009, issue of Cancer
Full Post: Inherited factors play key role in breast cancer