Exercise after menopause lowers breast cancer risk
Scientists have identified a molecular cause behind the ravages of old age and in doing so have also shown how a natural process for fighting cancer in younger persons can actually promote cancer in older individuals. Cellular senescence, the process by which biological cells stop dividing in response to stress or damage to their DNA,
Full Post: New insights into cellular senescence
Several studies had previously suggested that regular physical exercise reduces the breast cancer risk of women.
However, it had been unknowned just how much exercise women should take in which period in life in order to benefit from this protective effect. Moreover, little was known about which particular type of breast cancer is influenced by physical activity.
Answers to these questions are now provided by the results of the MARIE study, in which 3,464 breast cancer patients and 6,657 healthy women between the ages of 50 and 74 years were questioned in order to explore the connections between life style and breast cancer risk. Participants of the study, which was headed by Professor Dr. Jenny Chang-Claude and conducted at the German Cancer Research Center and the University Hospitals of Hamburg-Eppendorf, were questioned about their physical activity during two periods in life: from 30 to 49 years of age and after 50.
A comparison between control subjects and breast cancer patients showed that women in the control group had been physically more active than patients. The scientists calculated the relative breast cancer risks taking account of the effect of other risk factors. Results show that the risk of developing breast cancer after menopause was lower by about one third in the physically most active MARIE participants compared to women who had generally taken little physical exercise.
For this reduced risk it is not necessary to work out hard at the gym. The women in the physically most active group, for example, walked for two hours every day and cycled for one hour, while the most inactive study participants walked for only about 30 minutes every day. The epidemiologists also discovered that physical activity in the postmenopausal period is particularly beneficial for reducing breast cancer risk.
A closer look at the types of breast cancer revealed that physically active women are less frequently affected, in particular, by tumors that form receptors for the two female sexual hormones, estrogen and progesterone. These malignant ‘hormone receptor positive tumors’ accounted for 62.5 percent of breast cancers among MARIE participants. Other tumor markers, such as HER2 receptor formation or differentiation stage of cancer cells, were found to be unrelated to physical activity.
The effect of physical activity was independent of weight gain, total energy intake or body mass index. Therefore, researchers assume that physical exercise reduces the risk of cancer through hormonal mechanisms instead merely by a reduction of body fat or other changes in physical constitution, as it has often been assumed.
“It doesn’t always have to be sports,” says Associate Professor Dr. Karen Steindorf of DKFZ, who has headed this analysis. “In our calculations we have also taken account of activities such as gardening, cycling or walking to the shops. Our advice to all women is therefore to stay or become physically active also in the second half of your life. You will not only reduce your risk of breast cancer, but it has been proven that your bones, heart and brain also benefit from it.”
Exercise is good for more than just your waistline. A recent study presented at the American Association for Cancer Research’s Seventh Annual International Conference on Frontiers in Cancer Prevention Research suggests that regular physical activity can lower a woman’s overall risk of cancer - but only if she gets a good night’s sleep. Otherwise, lack of
Full Post: Exercise can lower a woman’s overall risk of cancer
According to a new study, published in the November issue of Diabetes Care , a majority of diabetics avoid physical activity because they worry about exercise-induced hypoglycemia (low blood sugar) and severe consequences including loss of consciousness. Despite the well-known benefits of exercise, this new study builds on previous investigations that found more than 60
Full Post: Fear of hypoglycemia a barrier to exercise for type 1 diabetics
New research out of the University of Pittsburgh indicates that patients’ perceptions of their own health and balance have an impact on how much they walk. The study was originally published in Physical Therapy (December 2008), the scientific journal of the American Physical Therapy Association (APTA). “The purpose of this cross-sectional study was to investigate
Full Post: Perception of health and balance has direct impact on walking activity
Researchers in New Zealand say though exercise is known to be one of the essential components which improve and enhance the quality of life, it is unfortunately underused. A new study by researchers from the University of Otago says physical exercise is a valuable tool for effectively improving the quality of life with regard to
Full Post: Exercise on doctors orders!
A recent international study fails to support the common belief that the number of calories burned in physical activity is a key factor in rising rates of obesity. Researchers from Loyola University Health System and other centers compared African American women in metropolitan Chicago with women in rural Nigeria. On average, the Chicago women weighed
Full Post: Exercise may not be key to obesity epidemic