Exposure to folic acid antagonists during pregnancy has risks
A new study shows that men are more likely to lose vision as a result of a particular cause of intracranial hypertension, or increased pressure in the brain, than women with the condition. The research is published in the October 15, 2008, online issue of Neurology, the medical journal of the American Academy of Neurology.
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Exposure to folic acid antagonists during pregnancy is associated with a higher risk of placenta-mediated adverse outcomes such as preeclampsia, placental abruption, fetal growth restriction or fetal death reports a retrospective cohort study published in CMAJ (pdf).
Folic acid antagonists include a broad range of drugs used to treat epilepsy, mood disorders, hypertension and infections. As approximately 50% of pregnancies in industrialized countries like Canada are unplanned, there is a risk of unintended exposure to these medications.
The study, conducted by researchers from Ottawa, Montreal, Saskatoon and Hunan, China looked at 14 982 women who had taken folic acid antagonists one year prior to delivery and 59 825 women who did not. Dr. Shi Wu Wen and co- researchers found that maternal exposure to folic acid antagonists was associated with a slightly higher risk of adverse pregnancy outcomes. They suggest re-classifying some folic acid antagonists and recommend increased folic acid supplements for women requiring folic acid antagonists during pregnancy.
In a related commentary, Dr. Joel Ray suggests the research study presents some “thought-provoking findings, but the results may not be ready for adoption by clinical practitioners or drug policy makers.” He cites some real concerns with the study design and the need for clinically relevant finding as cautions about translating findings into practice.
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Women who are exposed to hairspray in the workplace during pregnancy have more than double the risk of having a son with the genital birth defect hypospadias, according to a new study published today in the journal Environmental Health Perspectives. The study is the first to show a significant link between hairspray and hypospadias, one
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Patients receiving drug eluting stents (DES) - stents coated with medication to prevent narrowing of the artery - as part of an angioplasty had better outcomes one year later than patients with bare metal stents, according to a new study to be published in CMAJ. Mortality in the first 30 days for people with drug
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Cigarette smoking during pregnancy is associated with potentially harmful changes in both maternal and fetal thyroid function, according to a new study accepted for publication in The Endocrine Society’s Journal of Clinical Endocrinology & Metabolism ( JCEM ). “We studied the influence of cigarette smoking on thyroid function of two groups of women at different
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A team effort between Australian and Chinese scientists could save the lives of many Chinese babies. The team from the Xi’an Jiaotong University, The George Institute for International Health and Sydney University’s School of Public Health, have been involved in a new study in China which has revealed the significant impact of iron supplements during
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