Hexokinase-1 gene variation associated with widely used marker of blood glucose concentration
Abnormal heart rhythms - arrhythmias - are killers. They strike without warning, causing sudden cardiac death, which accounts for about 10 percent of all deaths in the United States. Vanderbilt investigators have discovered a new molecular mechanism associated with arrhythmias. Their findings, reported in The Journal of Clinical Investigation, could lead to novel arrhythmia treatments.
Full Post: Discovery could lead to novel arrhythmia treatments
Scientists have found that genetic variation at the hexokinase-1 gene is linked to variation in the blood concentration of glycated hemoglobin, an index of long-term blood glucose concentration widely used in the follow-up of diabetes patients.
The study, conducted by researchers from the Brigham and Women’s Hospital in Boston, USA, is published December 19 in the open-access journal PLoS Genetics .
Diabetes is a leading cause of morbidity and mortality in both the developed and developing world. Because the main metabolic characteristic of diabetes is increased blood glucose concentration, the researchers sought to uncover the genetic determinants of glycated hemoglobin. Lead author Guillaume Paré and his team analyzed glycated hemoglobin concentration in a subset of 14,618 women from the Women’s Genome Health Study, a large-scale study seeking to identify patterns of genetic variations that predict future disease states in otherwise healthy American women.
Using new technologies to study genetic variation on a whole genome basis, the group found that variations at the hexokinase-1 gene are an important determinant of glycated hemoglobin concentrations. Hexokinase-1 encodes the enzyme hexokinase, responsible for the first metabolic step in glucose utilization and a likely candidate for the control of glucose metabolism.
While further work will be needed to fully understand the metabolic role of these genetic variants, it is hoped that this discovery could lead to a better understanding of the mechanisms underlying diabetes and its complications.
Patients with type 2 diabetes who have poor glycemic control and a certain genetic variation have an increased risk of coronary artery disease, according to a study in the November 26 issue of JAMA, the Journal of the American Medical Association. Among the known risk factors for cardiovascular disease, diabetes mellitus ranks as one of
Full Post: Genetic variation for persons with diabetes linked to greater risk of coronary artery disease
Metabolic diseases - in particular the increasingly prevalent type 2 diabetes - are caused by a complex interaction between genetic disposition and unfavorable lifestyle, above all unbalanced diet and too little physical exercise. Researchers at the Helmholtz Zentrum M? have now for the first time been able to show a relationship between the genetic make-up
Full Post: Genetic variation in metabolism identified
Common genetic polymorphisms induce major differentiations in the metabolic make-up of the human population, according to a paper published November 28 in the open-access journal PLoS Genetics. An international team of researchers, led by Karsten Suhre, has conducted a genome-wide association study with metabolomics, identifying genetic variants in genes involved in the breakdown of fats.
Full Post: Study identifies genetic variants giving rise to differences in metabolism
deCODE genetics has announced the discovery by an international consortium of scientists from deCODE and major European and US academic institutions of a single letter variation in the human genome (SNP) that is associated with increased fasting glucose levels and risk of type 2 diabetes (T2D). deCODE will employ its CLIA-registered genotyping laboratory and existing
Full Post: deCODE to integrate new genetic risk factor for type 2 diabetes into its personal genome scan service
According to new research from the U.S. eating too many eggs may increase the risk of a person developing type 2 diabetes - and this applies to both men and women. The researchers from Brigham and Women’s Hospital and Harvard Medical School examined data from two completed randomized trials - the Physicians’ Health Study I
Full Post: Eating too many eggs may raise your risk of type 2 diabetes