High-fat diet during pregnancy makes new cells in fetal brain that cause early onset obesity
A novel protein marker has been found that identifies rare adult liver stem cells, whose ability to regenerate injured liver tissue has the potential for cell-replacement therapy. For the first time, researchers at the University of Pennsylvania School of Medicine led by Linda Greenbaum, MD, Assistant Professor of Medicine in the Division of Gastroenterology, have
Full Post: Discovery of stem cells with potential to regenerate injured liver tissue
A study in rats shows that exposure to a high-fat diet during pregnancy produces permanent changes in the offspring’s brain that lead to overeating and obesity early in life, according to new research by Rockefeller University scientists.
This surprising finding, reported in the Nov. 12 issue of the Journal of Neuroscience , provides a key step toward understanding mechanisms of fetal programming involving the production of new brain cells that may help explain the increased prevalence of childhood obesity during the last 30 years.
“We’ve shown that short-term exposure to a high-fat diet in utero produces permanent neurons in the fetal brain that later increase the appetite for fat,” says senior author Sarah F. Leibowitz, who directs the Laboratory of Behavioral Neurobiology at Rockefeller. “This work provides the first evidence for a fetal program that links high levels of fats circulating in the mother’s blood during pregnancy to the overeating and increased weight gain of offspring after weaning.”
Research in adult animals by Leibowitz and others has shown that circulating triglycerides stimulate brain chemicals known as orexigenic peptides, which in turn spur the animals to eat more. Scientists also have shown that obese and diabetic mothers produce heavier children and that exposure to fat-rich foods early in life leads to obesity in adulthood. These studies suggested that food intake and body weight may be programmed during fetal development. But little was known about the mechanism underlying this programming.
Leibowitz and her colleagues have identified mechanisms in the brain that explain this programming. They looked at the effects of feeding pregnant rats a high fat diet for two weeks compared with a balanced diet containing a moderate amount of fat. The researchers found that rat pups born to mothers who consumed the high fat diet, even after the diet had been removed at birth, ate more, weighed more throughout life, and began puberty earlier than those born to mothers who ate a balanced diet for the same two week period. They also had higher levels of triglycerides in the blood at birth and as adults and greater production of brain peptides that stimulate eating and weight gain.
Leibowitz and her colleagues then looked at the pups’ brain development during the last week of pregnancy. They examined the number and types of neurons being born and made a surprising discovery: The pups from the mothers fed high fat diets had, in utero, a much larger number of neurons that produce the appetite-stimulating orexigenic peptides - and they kept them throughout their lives. During gestation, the mother’s fat-rich diet also stimulated the proliferation of neuronal precursor cells and their differentiation and migration to obesity-promoting centers in the brain. In rats on a balanced diet, these neurons were much fewer in number and appeared much later after birth.
“We believe the high levels of triglycerides that the fetuses are exposed to during pregnancy cause the growth of the neurons earlier and much more than is normal,” says Leibowitz.
The researchers hypothesize that because the mother must prepare her embryos to survive on her diet, they need to be born with the brain mechanisms that allow them to eat and metabolize it.
Leibowitz believes similar mechanisms may be operating in humans.
“We’re programming our children to be fat,” she says. “I think it’s very clear that there’s vulnerability in the developing brain, and we’ve identified the site of this action where new neurons are being born. We now need to understand how the lipids affect these precursor cells that form these fat-sensitive neurons that live with us throughout life.”
A study in the Dec. 1 issue of the journal Sleep is the first to show that high levels of prenatal smoking exposure strongly modify sleep patterns in preterm neonates, which places infants at a higher risk for developmental difficulties that could persist throughout early and middle childhood. Results indicate that preterm neonates born to
Full Post: High levels of prenatal smoking exposure affects sleep in early babies
Cigarette smoking during pregnancy is associated with potentially harmful changes in both maternal and fetal thyroid function, according to a new study accepted for publication in The Endocrine Society’s Journal of Clinical Endocrinology & Metabolism ( JCEM ). “We studied the influence of cigarette smoking on thyroid function of two groups of women at different
Full Post: Smoking during pregnancy impacts thyroid function of mother and fetus
Rats whose mothers were fed alcohol during pregnancy are more attracted to the smell of liquor during puberty. Researchers writing in BioMed Central’s open access journal Behavioral and Brain Functions have shown that rats exposed during gestation find the smell of alcohol on another rat’s breath during adolescence more attractive than animals with no prior
Full Post: Important relationship between fetal and adolescent alcohol experiences
A course of water aerobics classes has been shown to reduce the amount of pain-killing medication women request during labor. Research published in BioMed Central’s open access journal Reproductive Health has shown that, as well as being safe, the gentle exercise has the benefit of making it easier to give birth. Rosa Pereira led a
Full Post: Water aerobics make it easier to give birth
The latest report from the Australian Institute of Health and Welfare - Australia’s Mothers and Babies 2006 - says that women are waiting longer to start a family. According to the report the average age of mothers giving birth in Australia is just under 30 years of age, and the average age of first-time mothers
Full Post: Women waiting longer to start a family