Humoral immunity in kidney transplantation



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There are more than 76,000 end-stage renal disease patients waiting for one of the 17,000 kidneys transplanted each year, making a host rejection an unacceptable waste.

Kidney transplantation is the preferred treatment for patients with end-stage renal disease. As the demand for organs exceeds the supply, blood group (ABO)-incompatible kidney transplantations have gained much importance and humoral immunity is of crucial importance in ABO-incompatible transplants. Humoral immunity is the immune response triggered by antibodies expressed in bodily fluids, which, in turn, plays a vital part in a transplant patient’s immune response to the donour organ. Although initial outcomes were poor, meanwhile more than 200 ABO-incompatible kidney transplantations have been performed successfully in Europe thanks to the improvements in managing humoral immunity. These treatment protocols rely on strategies to remove ABO antibodies before and after transplantation, to impair the B cell compartment and to use immunomodulators such as intravenous immunoglobulin.

Aimed especially at the clinician, this book presents recent insights into the characterization and pathogenetic role of humoral immunity in chronic allograft injury and investigates the perspectives for novel immunosuppressive therapies to control antibody production after transplantation. It is an indispensable update for all those involved in the care of kidney transplant patients.

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A noninvasive test that analyzes proteins in the urine can correctly identify patients whose transplanted kidneys are failing, according to a study appearing in the February 2009 issue of the Journal of the American Society Nephrology (JASN). The results might allow physicians to more accurately monitor transplant patients and to fine-tune the immunosuppressive therapies prescribed

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A Johns Hopkins transplant surgeon has found strong evidence that women over 45 are significantly less likely to be placed on a kidney transplant list than their equivalent male counterparts, even though women who receive a transplant stand an equal chance of survival. “As woman age, that discrepancy widens to the point where woman over

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Individuals who are obese face certain risks when donating their kidneys, but their kidney function remains strong one year later, according to a paper being presented at the American Society of Nephrology’s 41st Annual Meeting and Scientific Exposition in Philadelphia, Pennsylvania. As the waiting list for kidney transplants grows, transplant centers are working to facilitate

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Biopharmaceutical company Kiadis Pharma announces that it has successfully completed treatment of the last patient on its ATIR phase I/II clinical trial. ATIR, a donor lymphocyte cell based product, is under development to prevent acute Graft versus Host Disease (GvHD) and allow early immune reconstitution following a mismatched bone marrow transplantation. Nineteen end stage

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A landmark study published in the New England Journal of Medicine (NEJM) demonstrates that use of a specially-designed machine to store kidneys for transplantation offers significant benefits in kidney survival and function when compared to those stored in a traditional “ice box”, or cold storage. Unlike the icebox, the LifePort(R) Kidney Transporter monitors the temperature

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