Link between mouthwash and oral cancer in dispute
Researchers at The Ohio State University Comprehensive Cancer Center have discovered that a molecule implicated in leukemia and lung cancer is also important in muscle repair and in a muscle cancer that strikes mainly children. The study shows that immature muscle cells require the molecule, called miR-29, to become mature, and that the molecule is
Full Post: Study links MiR-29 molecule to muscle maturation, muscle cancer
A battle has broken out between dental health experts over claims by an academic researcher that the alcohol present in mouthwash products increases the risk of oral of cancer.
The warning comes in an article published in the Australian Dental Journal by Associate Professor of Oral Medicine, Dr. Michael McCullough and says there is sufficient evidence that mouthwashes containing alcohol increase the risk of oral cancer.
Dr. McCullough carried out a review of research into how alcohol is involved in the development of oral cancer and looked at literature which has linked alcohol-containing mouthwashes and oral cancer and as a result he has called for mouthwashes containing alcohol to be reclassified as ‘prescription only’ and removed from supermarket shelves.
But not everyone agrees and some experts say such products are more likely to prevent the disease.
The head of the University of Queensland’s School of Dentistry, Professor Laurence Walsh, says there are a number of reasons why some mouth rinses would actually reduce the chance of the cancer because their action impairs the production of molecules like acetaldehyde that have cancer-causing effects.
Professor Walsh says there is evidence which has international support that mouth rinses containing alcohol used to reduce bacteria which produce acetaldehyde are not linked to cancer.
But according to Dr. McCullough acetaldehyde, a toxic by-product of alcohol suspected to be carcinogenic, may accumulate in the oral cavity when mouthwash is used and he says there is no evidence showing the molecule could either suppress or prevent cancer.
Some cancer experts suggest there may be a potential risk in using alcohol mouth washes and caution against the daily use of a powerful alcoholic-based mouthwash especially by smokers to mask the smell of cigarette smoke - they say more research is needed into such products.
They advise anyone finding anything unusual in their mouths, such as unexplained lesions, to see their dentist or doctor.
The Australian Dental Association, which endorses the product Listerine, has called the review “very interesting” but says there is no definite proof that alcohol contained in mouthwash products can cause cancer.
The Dental Association says a link between heavy drinking and cancer has been established and therefore there is a possible link with long term multiple uses of alcohol contained in mouthwashes but more research is needed before this can be definitely said to exist.
A wide body of research has linked smoking and alcohol consumption to the development of oral cancer - in Australia each year over 800 new cases are reported.
Chronic drinking is a risk factor for colorectal cancer, possibly through the effects of acetaldehyde, which is created by the alcohol dehydrogenase (ADH) enzyme. This study investigated if a polymorphism of the ADH1C gene that is found in Caucasians may effect acetaldehyde concentrations. Findings confirm ADH1C*1 as a genetic risk marker for colorectal tumors among
Full Post: Drinkers with the ADH1C gene at greater risk of colorectal cancer
Raptor Pharmaceuticals Corp. has announced positive results in its Phase IIa study of oral 4-methylpyrazole (”4-MP”) in subjects with ALDH2 deficiency, or ethanol intolerance, as the initial development stage of its Convivia program. Convivia is Raptor’s proprietary oral formulation of 4-MP designed to reduce systemic acetaldehyde exposure and related symptoms in ALDH2 deficient persons following
Full Post: Raptor Pharmaceuticals announces positive results for Convivia program
In the run up to the New Year’s Eve festivities a scientist in Britain has chosen an opportune moment to warn revellers that drinking alcohol, even in relatively small amounts, can increase a tipplers risk of developing cancer. Dr. Rachel Thompson, from the World Cancer Research Fund (WCRF) says that a large glass of
Full Post: Time to celebrate? Be warned! One tipple a day increases the risk of cancer
A new review outlines potential pharmaceutical, dietary, surgical, and other approaches to reducing the risk of breast cancer among women in the United States, and examines the evidence for specific recommendations. The review says risk reduction strategies for women at average risk of breast cancer should focus primarily on lifestyle factors. Among the recommendations: aside
Full Post: A new review of breast cancer prevention strategies in the U.S.
Worldwide, more than 500,000 new cases of cancer of the mouth are diagnosed each year. The majority of these cancers are found too late, causing many people to die within five years of finding out they have cancer. There exists much information addressing issues related to the patient who has undergone surgery or chemotherapy but
Full Post: Many mouth cancers found too late