Obesity has minimal impact on ovarian cancer survival
For the first time, researchers have found that a modified form of a naturally occurring protein, N-cadherin, could prevent blocked arteries. Blocked arteries are a major cause of heart attacks and strokes. The thickening of the artery wall, which occurs due to the build-up of fat and cells in the artery wall leads to
Full Post: Protein could prevent blocked arteries
Obesity affects health in several ways, but new research shows obesity can have minimal impact on ovarian cancer survival.
A study by researchers at the University of Alabama at Birmingham (UAB) Comprehensive Cancer Center found ovarian cancer survival rates are the same for obese and non-obese women if their chemotherapy doses are closely matched to individual weight.
The findings contradict earlier research that shows obese women have lower ovarian cancer survival rates compared to non-obese patients. In the UAB study, such survival disparity disappeared when chemo doses were calculated by actual body weight rather than a different dosing standard, said Kellie Matthews, M.D., a UAB gynecologic oncologist and lead author on the new study.
“Often chemotherapy dosing is calculated using ‘ideal’ body weight as a guide. We found using actual body weight works best, and it wipes away much of the difference in survival rates between obese and non-obese patients,” Matthews said.
The results are published online in the journal Gynecologic Oncology .
Researchers reviewed the medical records of 304 patients diagnosed with an aggressive form of the disease called epithelial ovarian cancer. Patients were of similar cancer stage and grade, and all had surgery followed by chemo.
The analysis showed that when actual body weight was used in chemo dosing the overall survival is 40 months for non-obese patients and 47 months for obese patients, not a significant difference, Matthews said. Similar outcomes are seen in obese and non-obese cancer survivors being monitored for recurrence of their ovarian cancer.
UAB’s chemo dosing formula includes actual weight, body mass index (BMI) and other factors, Mathews said. Obesity is defined as a BMI (BMI: kg/m2) of 30 or more.
The study authors acknowledged that while it was possible to follow this formula and remove obesity as a negative indicator for ovarian cancer survival, obesity still puts women at increased risk for complications related to cancer surgery, such as greater blood loss and stubborn-to-heal incisions. Also, research shows obese women are more likely to have other health problems such as diabetes and cardiovascular disease that may impact cancer treatment.
A new epidemiological study has found that among women who have never used menopausal hormone therapy, obese women are at an increased risk of developing ovarian cancer compared with women of normal weight. Published in the February 15, 2009 issue of CANCER, a peer-reviewed journal of the American Cancer Society, the research indicates that obesity
Full Post: Obesity raises ovarian cancer risk
A new epidemiological study has found that among women who have never used menopausal hormone therapy, obese women are at an increased risk of developing ovarian cancer compared with women of normal weight. Published in the February 15, 2009 issue of CANCER, a peer-reviewed journal of the American Cancer Society, the research indicates that
Full Post: Study links obesity to elevated risk of ovarian cancer
New research published in the January issue of the Journal of the American College of Surgeons shows that morbidly obese patients are at higher risk than normal weight patients for complications after colectomy - surgical removal of all or part of the colon - for the treatment of cancer. Obese patients are more likely than non-obese patients
Full Post: Morbidly obese patients face high risk for complications after colectomy
According to the latest research obese women are more impulsive than other females but this does not apply to obese men. The new study found that obese women display significantly weaker impulse control than normal-weight women, but between obese and normal-weight men, the impulsivity levels are nearly the same. The study by researchers at the
Full Post: Obese women more impulsive
A review of previously published studies suggests that rates of adverse outcomes for mothers or pregnant women and newborn babies, such as gestational diabetes and low birth weight, may be lower after bariatric surgery compared with pregnant women who are obese, according to an article in the November 19 issue of JAMA, the Journal of
Full Post: Risk of maternal and newborn complications may be lower after bariatric surgery