Psoriasis sufferers more likely to have higher levels of leptin



Men and women have about the same in-hospital death rate for heart attack - but women are twice as likely to die if hospitalized for a more severe type of heart attack, according to a report in Circulation: Journal of the American Heart Association. Among patients with ST elevation myocardial infarction (STEMI) in a recent

Full Post: Gender disparity gap in heart attack care still present

Patients with the skin disease psoriasis appear more likely to have higher levels of leptin (a hormone produced by fat cells that may contribute to obesity and other metabolic abnormalities) than persons without psoriasis, according to a report in the December issue of Archives of Dermatology.

Psoriasis is an autoimmune disease that results in a red, scaly rash. “Associations among psoriasis, obesity, hypertension, cardiovascular diseases, diabetes mellitus and metabolic syndrome have been reported,” the authors write as background information in the article. “Although the underlying mechanisms may be complex, the ‘obesity of psoriasis’ is thought to be a key link to cardiovascular diseases, including diabetes mellitus, stroke, heart disease, hypertension and myocardial infarction [heart attack].”

Yi-Ju Chen, M.D., of the Taichung Veterans General Hospital and National Chung Hsing University, Taiwan, and colleagues studied 77 patients with psoriasis and 81 individuals who were the same age and sex but did not have psoriasis. In 2006 and 2007, the researchers collected clinical characteristics of the participants, including age, sex, height, weight, any other diseases they had and the severity of their psoriasis. Blood samples were analyzed for levels of leptin, a hormone that helps control food intake, body weight and fat stores and also is related to immune and inflammatory processes.

Individuals with psoriasis were more likely than controls to be obese and to have hypertension (high blood pressure) and elevated blood glucose levels or diabetes. High blood levels of leptin were found more often in females, the obese and those with high blood pressure, metabolic syndrome (a grouping of cardiovascular risk factors that includes hypertension and high cholesterol) or psoriasis.

“After adjustment for sex, body mass index and conventional cardiovascular risk factors (including hypertension and metabolic syndrome), psoriasis was independently associated in our study with hyperleptinemia [high leptin levels],” the authors write. “In addition, hyperleptinemia in psoriasis is associated with higher risk of developing metabolic syndrome. This novel finding links the chronic inflammation status of psoriasis with metabolic disturbances.”

The high circulating leptin levels in individuals with psoriasis may derive not only from fat tissue but also from inflammation, they continue. “Body weight loss has been reported to significantly decrease leptin levels and improve insulin sensitivity and may reduce the likelihood of developing metabolic syndrome and adverse cardiovascular diseases,” the authors conclude. “Body weight loss could potentially become part of the general treatment of psoriasis, especially in patients with obesity.”

http://archderm.ama-assn.org/

Link




Obese people who don’t have high cholesterol or diabetes might think they’re healthy - despite the extra pounds. But new Ohio University research suggests that obesity raises levels of the hormone leptin, which can be as big a threat to the cardiovascular system as cholesterol. Tadeusz Malinski and colleagues have published the first study to directly

Full Post: Obesity raises levels of hormone leptin



Sleeping less than seven and a half hours per day may be associated with future risk of heart disease, according to a report in the November 10 issue of Archives of Internal Medicine. In addition, a combination of little sleep and overnight elevated blood pressure appears to be associated with an increased risk of the

Full Post: Lack of sleep tied to greater risk of heart disease



When an obesity drug called Leptin was first discovered by scientists 13 years ago, experts hoped the appetite-suppressing hormone would be a possible cure for obesity. Leptin failed to realise those expectations and it was discovered that overweight people became unresponsive to Leptin very quickly due to the development of resistance in the brain

Full Post: Fat busting drug Leptin could make a comeback



A traditional Mediterranean diet with an additional daily serving of mixed nuts appears to be useful for managing some metabolic abnormalities in older adults at high risk for heart disease, according to a report in the December 8/22 issue of Archives of Internal Medicine. The metabolic syndrome is a set of metabolic abnormalities that includes

Full Post: Nuts and Mediterranean diet appear to help metabolic syndrome



The risk of obese people developing the metabolic syndrome that leads to diabetes, hypertension, and heart disease, can not be solved by a one-size-fits-all diet programme, according to new scientific findings. The results of Lipgene, a five year EU research programme, show that personalised nutrition diets based on peoples genetic make-up will be the way

Full Post: Diet may regulate obesity health risks, but genes decide, says new research