Researchers create tiny, implantable device that captures and kills cancer cells in the bloodstream
New research shows that the delicate balance between maximum clinical impact and toxicity may not be quite as fragile as scientists had previously believed. The study, published by Cell Press in the December issue of the journal Cancer Cell, is likely to have a major impact on the future design and implementation of targeted cancer
Full Post: When less is more: Brief inhibition of cancer target is effective and less toxic
In a new tactic in the fight against cancer, Cornell University researcher Michael King has developed what he calls a lethal “lint brush” for the blood — a tiny, implantable device that captures and kills cancer cells in the bloodstream before they spread through the body.
The strategy, which takes advantage of the body’s natural mechanism for fighting infection, could lead to new treatments for a variety of cancers, said King, who is an associate professor of biomedical engineering.
In research conducted at the University of Rochester and to be published in an upcoming issue of the journal Biotechnology and Bioengineering, King showed that two naturally occurring proteins can work together to attract and kill as many as 30 percent of tumor cells in the bloodstream — without harming healthy cells.
King’s approach uses a tiny tubelike device coated with the proteins that could hypothetically be implanted in a peripheral blood vessel to filter out and destroy free-flowing cancer cells in the bloodstream.
To capture the tumor cells in the blood, King used selectin molecules –proteins that move to the surface of blood vessels in response to infection or injury. Selectin molecules normally recruit white blood cells (leukocytes), which “roll” along their surfaces and create an inflammatory response — but they also attract cancer cells, which can mimic the adhesion and rolling process.
Once the cancer cells adhered to the selectin on the microtube’s surface, King exposed them to a protein called TRAIL (for Tumor Necrosis Factor Related Apoptosis-Inducing Ligand), which binds to two so-called “death receptors” on the cancer cells’ surface, setting in motion a process that causes the cell to self-destruct.
The TRAIL then releases the cells back into the bloodstream to die; and the device is left free to work on new cells.
“It’s a little more sophisticated than just filtering the blood, because we’re not just accumulating cancer cells on the surface,” King said.
King’s research showed that the device can capture and kill about 30 percent of cancer cells flowing past it a single time, with the potential to kill more in the closed-loop system of the body. Used in combination with traditional cancer therapies, King said, the device could remove a significant proportion of metastatic cells, “and give the body a fighting chance to remove the rest of them.”
The team also showed that a system in which the cancer cells “roll” over the target molecules - presenting their entire surface to the molecules - is four times more effective than a static setup in which the cells and proteins make contact at a single point.
King’s group tested the device on prostate and colon cancer cells, but noted that it could also be customized with additional peptides or other proteins to target other types of cancer cells. “And if you could reduce or prevent metastasis, pretty much any cancer would be treatable,” he said.
But translating the research into a clinical application will take time, he added, and is still likely years away.
“The actual physical device, when it gets eventually tested in humans, will probably look a lot like an arteriovenous shunt [a small tube, or shunt, that diverts blood flow] with our protein coating,” he said.
“This has never been tried before. It’s a whole new way of approaching cancer treatment,” he added. “There’s a lot of work yet to be done, of course, before this actually helps people — but this is how it starts.”
Peregrine Pharmaceuticals, Inc. has announced that updated preliminary data from the first stage of its Phase II trial evaluating bavituximab in combination with docetaxel showed that 10 of 14 (71%) evaluable breast cancer patients achieved an objective tumor response according to RECIST criteria. The company also reported that patient screening has begun in the
Full Post: Peregrine Pharmaceuticals reports on phase II trial of Bavituximab plus Docetaxel in advanced breast cancer
UC Davis Cancer Center researchers report today the discovery of a molecule that targets glioblastoma, a highly deadly form of cancer. The finding, which is published in the January 2009 issue of the European Journal of Nuclear Medicine and Molecular Imaging , provides hope for effectively treating an incurable cancer. Glioblastoma is the most common
Full Post: Discovery of molecule that targets brain tumors
Molecules of sugar sitting on the surface of cancer cells are keys to the development of a new vaccine aimed at both treating and stopping the spread of certain types of cancers called carcinomas, which include prostate, breast, ovarian and lung, among others. Armed with a new two-year grant for $600,000 from the Gateway for
Full Post: Novel low-cost immunotherapy for cancer cells
Researchers have developed a new type of imaging compound that allows them to visualize viable breast cancer cells that have spread to the lungs in mice. The compound binds to a protein called HER2, which is found on the surface of some breast cancer cells, and it glows, or fluoresces, only when taken inside
Full Post: Glowing imaging compound allows detection of viable cancer cells in mice
Microvesicles - tiny membrane-covered sacs - released from glioblastoma cells contain molecules that may provide data that can guide treatment of the deadly brain tumor. In their report in the December 2008 Nature Cell Biology, which is receiving early online release, Massachusetts General Hospital (MGH) researchers describe finding tumor-associated RNA and proteins in membrane microvesicles called exosomes
Full Post: Microvesicles released from glioblastoma cells carry information that may guide treatment