Scientists discover an important new layer of regulation in the cell division cycle
Health officials in Cairns in the tropical northern part of Queensland, Australia are battling to contain an outbreak dengue fever in the region. In the latest attempt to make people sit up and take both notice and action, homeowners are being warned to clean up mosquito breeding areas in their backyards or risk fines
Full Post: Cairn’s residents threatened with fines over dengue outbreak
A Florida State University College of Medicine research team led by Yanchang Wang has discovered an important new layer of regulation in the cell division cycle, which could lead to a greater understanding of the way cancer begins.
Wang, an assistant professor of biomedical sciences at the College of Medicine, said the findings will lead to an improved ability to diagnose cancer and could lead to the design of new drugs that kill cancer cells by inhibiting cell reproduction. His paper on the discovery has been published in the journal Proceedings of the National Academy of Sciences .
“The correct timing of chromosome segregation during cell division is necessary to ensure normal, healthy growth,” Wang said. “Now we have discovered a previously undetected layer of regulation in how the chromosomes separate, which helps to ensure the correct timing and decreases the potential for the formation of cancerous growth.”
The cell division cycle is a collection of tightly regulated events that lead to cell duplication. The most important events are the doubling of the hereditary information encoded within a set of chromosomes, and the division of that duplicated information into two daughter cells that are genetically identical to each other and the mother cell.
The correct order of cell-cycle events is essential for successful cell division. Wang’s article addresses the role of a particular protein enzyme, Cdc14, in ensuring that cell division events occur in exactly the right order.
Defects in the regulation of the order of events can lead to cell death or the alteration of genetic information, which contributes to the formation of cancerous cells.
CANCER RESEARCH UK scientists have linked cancer clues in faulty cells to provide a new route to cancer development, reveals a study published in Developmental Cell. Cancer is a disease caused by uncontrolled cell growth and division and understanding the complex molecular networks inside cells which regulate these processes is fundamental to understanding what goes
Full Post: Scientists establish completely new route to cancer development
Biologists have discovered a mechanism that is critical to cytokinesis — nature’s completion of mitosis, where a cell divides into two identical daughter cells. The researchers have opened a new window on the assembly and activity of a ring of actin and myosin filaments that contract to pinch a cell at just the right time.
Full Post: New insights into cell division
An enzyme that lives in Methicillin-resistant Staphylococcus aureus (MRSA) and helps the dangerous bacterium to grow and spread infection through the human body has been visualised for the first time, according to a study out today in Proceedings of the National Academy of Sciences (PNAS). Now, armed with detailed information about the structure of
Full Post: MRSA’s weak point visualised by scientists
The Stowers Institute’s Rong Li Lab has published findings that shed light on the ability of cells to adapt to disruptions to their basic division machineries - findings that may help explain how cancer cells elude the body’s natural defense mechanisms or chemotherapy treatment. The work was published in the November 26 issue of Cell
Full Post: Researchers provide new insight into adaptive ability of cells
Ovarian cancer cells are “addicted” to a family of proteins produced by the notorious oncogene, MYC. Blocking these Myc proteins halts cell proliferation in the deadliest cancer of the female reproductive system, according to a presentation by University of California, Berkeley scientists at the American Society for Cell Biology (ASCB) 48th Annual Meeting, Dec. 13-17,
Full Post: Blocking Myc proteins stops ovarian cancer cell cycle in its tracks