Specialized kidney transporter improves transplant results
A marked increase in the effects of warfarin with bleeding has been seen in a small number of patients when concurrently treated with erythromycin, but most patients are unlikely to develop a clinically important interaction. This interaction has also been seen in a patient on nicoumalone (acenocoumarol). A case report describes an elderly woman on warfarin,
Full Post: Anticoagulants and Erythromycin
A landmark study published in the New England Journal of Medicine (NEJM) demonstrates that use of a specially-designed machine to store kidneys for transplantation offers significant benefits in kidney survival and function when compared to those stored in a traditional “ice box”, or cold storage.
Unlike the icebox, the LifePort(R) Kidney Transporter monitors the temperature and vascular performance of the organ in real time, while preserving it by pumping the kidney continuously with a cold solution, even while the organ is being transported to its intended recipient.
“This important study confirms the critical role that transportable machine perfusion can play in improving kidney transplant outcomes,” said David Kravitz, Chief Executive Officer of Organ Recovery Systems, the manufacturer of LifePort. “It also demonstrates that LifePort should have a central place in all transplantation programs, to help ensure the best possible patient outcomes.”
The international trial enrolled kidney pairs from 336 consecutive deceased donors in Europe and randomly assigned one kidney to machine perfusion and the other to static storage. Results showed that the odds of a delay in kidney function post transplant were reduced by almost half when machine perfusion was used compared with static cold storage. Delay in kidney function, or DGF, is a factor that is known to adversely affect the long-term outcome of kidney transplantation. The study also showed that the LifePort kidneys were 48 percent less likely to fail within the first year post-transplant compared to those kidneys stored in the traditional box of ice prior to transplantation. This is the first randomized, prospective study to directly compare the two methods of storing and transporting organs for transplantation.
“For the first time in the United States, the number of those waiting for a life-saving transplant has passed 100,000,” said Joseph Vassalotti, MD, Chief Medical Officer of the National Kidney Foundation. “Any new method like the one demonstrated in this study, that will help maximize the available organs and potentially reduce the need for re-transplantation, is vitally important for patients and the professionals who care for them.”
More than 1.5 million people worldwide suffer from end stage renal disease, for which a kidney transplant is the preferred treatment option. With a continuing global shortage of organs for transplantation, it is important to find ways of increasing not just the number of kidneys available but also the quality of organs for transplantation to improve the long-term outcome for recipients. By improving the quantity and quality of organs for transplant, both improvements in clinical outcomes and cost savings to health systems are likely to occur.
The LifePort provides a sealed, sterile, protected environment where a physiologic solution is gently pumped through the kidney at cold temperatures to minimize damage while the organ is outside the body. The LifePort is lightweight and portable allowing organs to be perfused and evaluated from the time of recovery until transplant. It can travel unaccompanied by land or air, safely transporting the kidneys across town or between states.
The Machine Preservation Trial was an investigator-driven study, run by an independent Scientific Steering Committee across The Netherlands, Belgium and Germany, with Eurotransplant (an international organ exchange organization) collaborating as study coordinators. The Machine Preservation trial was sponsored by Organ Recovery Systems of Chicago, USA, manufacturers of the LifePort Kidney Transporter.
A Johns Hopkins study finds that HIV-positive kidney transplant recipients could have the same one-year survival rates for themselves and their donor organs as those without HIV, provided certain risk factors for transplant failure are recognized and tightly managed. “Kidney transplantation is a viable and necessary option for HIV-positive patients with chronic kidney disease, especially
Full Post: Kidney transplant survival can be long-term for people with HIV
There are more than 76,000 end-stage renal disease patients waiting for one of the 17,000 kidneys transplanted each year, making a host rejection an unacceptable waste. Kidney transplantation is the preferred treatment for patients with end-stage renal disease. As the demand for organs exceeds the supply, blood group (ABO)-incompatible kidney transplantations have gained much importance
Full Post: Humoral immunity in kidney transplantation
Individuals who are obese face certain risks when donating their kidneys, but their kidney function remains strong one year later, according to a paper being presented at the American Society of Nephrology’s 41st Annual Meeting and Scientific Exposition in Philadelphia, Pennsylvania. As the waiting list for kidney transplants grows, transplant centers are working to facilitate
Full Post: Health complications for obese kidney donors
For the first time in the world, transplant surgeons at Toronto General Hospital, University Health Network used a new technique to repair an injured donor lung that was unsuitable for transplant, and then successfully transplanted it into a patient. The use of this technique could significantly expand the lung donor organ pool and improve outcomes
Full Post: World-first technique used to repair an injured donor lung
Researchers in the U.S. have discovered a new cancer drug which effectively treats transplant rejections. The researchers from the University of Cincinnati (UC) say the new therapy for transplant patients, targets the antibody-producing plasma cells that can cause organ rejection. According to a study by Dr. Steve Woodle and colleagues, the cancer drug bortezomib which
Full Post: New therapy for transplant rejection