Tribendimidine shows promise for intestinal worm infections
In the January 2009 issue of the American Journal of Medicine, Florida Atlantic University researcher Charles H. Hennekens, M.D., the first Sir Richard Doll Research Professor in the Charles E. Schmidt College of Biomedical Science and a renowned expert who has revealed numerous causal, therapeutic and preventive factors in the treatment and prevention of cardiovascular
Full Post: An explanation of how statins cause low rates of muscle symptoms
Researchers have reported positive results from a safety and efficacy study pertaining to tribendimidine, a broad-based treatment for intestinal worm infections.
The group’s results demonstrate the success of the new drug from China versus that of the standard albendazole for the treatment of hookworm, large roundworm, whipworm, and, for the first time, threadworm and tapeworm.
The study was jointly implemented by researchers from the Swiss Tropical Institute in Basel, the National Institute of Parasitic Diseases (IPD) in Shanghai, the Yunnan Institute of Parasitic Diseases in Simao, China, and the Jiangsu Institute of Parasitic Diseases in Wuxi, China. Details are published October 15th in the open-access journal PLoS Neglected Tropical Diseases.
Globally, more than one billion people are infected with intestinal worms. These chronic infections negatively impact on child and maternal health, nutritional status, physical performance, and cognitive development. The current control strategy relies on drugs to reduce morbidity, ideally complemented by the provision of safe water and sanitation to curb transmission. Only four drugs are currently recommended by the World Health Organization for treating soil-transmitted helminth infections, making the potential development of drug resistance a concern. Tribendimidine belongs to a different chemical class than current worm treatments. The drug had been developed at IPD and Shandong Xinhua Pharmaceutical in Zibo, China, and was approved by the China State Food and Drug Administration in 2004.
The community-based study involved 123 individuals who were screened for intestinal helminth infections, and randomly allocated to tribendimidine or the widely used albendazole treatment (both at 200 mg for children aged 5-14 years and 400 mg for individuals aged 15 years and above). The researchers’ administration of a single oral dose of tribendimidine cured up to 92% of the common soil-transmitted helminth infections in humans in a highly endemic setting in China. Encouraging results were also found against threadworm and tapeworm infections. After treatment, these two parasites were absent in 55% and 67% of those initially infected, respectively. The infection intensity of large roundworms and hookworms was significantly reduced by both drugs, and no adverse treatment-related events were noted among the final study cohort.
The obtained results need to be validated in larger patient cohorts and different epidemiological settings, and repeated dosing should be tested to further improve treatment outcomes.
Hundreds of millions of people, mainly in developing countries, are disabled by infectious diseases, according to the World Health Organization. More than 12 million people in 88 countries are infected with leishmaniasis, a parasitic disease spread by the bite of infected sand flies. Nearly 2 million new cases are reported and about 70,000 people die
Full Post: Researchers hunt for new drugs for Leishmaniasis
A study published this month in The New England Journal of Medicine, “Mortality Attributable to Smoking in China,” provides an estimate of the number of premature deaths in China in 2005 that were caused by smoking. The study, carried out by a multinational team led by researchers at Tulane University School of Public Health and
Full Post: Smoking prevention programs badly needed in China
In the quest to develop the next generation of anti-infective medicine, Griffith University and Pfizer, the world’s largest research-based pharmaceutical company, announced a leading partnership today. Griffith University’s Eskitis Institute for Cell and Molecular Therapies investigates novel drug- and cell-based therapies for human diseases in the areas of cancer, infection and immunity, neglected diseases,
Full Post: Griffith University and Pfizer in new partnership to unlock nature’s cure for infections
The results of two new large scale trials show that the combination of dihydroartemisinin and piperaquine (DHA+PQP) not only is effective against uncomplicated malaria in a way which is comparable to other artemisinin-based combination therapies (ACTs), but it also protects patients against new infections for at least two months after treatment. The DHA/PQP combination is
Full Post: Combo malaria treatment dihydroartemisinin and piperaquine shows promise
RHEI Pharmaceuticals, Inc. has announced that the final clinical trial for Tibozole, a locally active antifungal with low dose miconazole in a patented mucoadhesive system, has been initiated in China. This will be the last clinical trial conducted for submission of the New Drug Application (NDA) to the State Food and Drug Administration (SFDA) in China.
Full Post: RHEI Pharmaceuticals starts final trial of Tibozole in China